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Article

Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.

Pharmaceutical research - 1 Oct 2008

Rodrigues-Díez Raquel, Carvajal-González Gisselle, Sánchez-López Elsa, Rodríguez-Vita Juan, Rodrigues Díez Raúl, Selgas Rafael, Ortiz Alberto, Egido Jesús, Mezzano Sergio, Ruiz-Ortega Marta

Abstract excerpt

PURPOSE: Tubulointerstitial fibrosis is a final common pathway to end-stage chronic kidney diseases, which are characterized by elevated renal angiotensin II (AngII) production. This peptide participates in kidney damage inducing fibrosis and epithelial mesenchymal transition (EMT). Our aim was to describe potential therapeutic targets in AngII-induced EMT, investigating the blockade of different intracellular...

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Identifiers

PMID: 18633694
DOI: 10.1007/s11095-008-9636-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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