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Article

A Critical Look at Growth Factors and Epithelial-to-Mesenchymal Transition in the Adult Kidney

11 Aug 2006

Abstract excerpt

In the adult kidney, the cellular phenotypes are maintained by a strict balance of growth factors. Epithelial-to-mesenchymal transition (EMT) is a program whereby injured epithelial cells that function as ion and fluid transporters become matrix remodelling mesenchymal cells. This process requires either transcriptional repression of genes that maintain the epithelial phenotype and transcriptional activation, or...

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PMID: 16902316
DOI: 10.1159/000094963

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