Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of angiotensin type 2 receptor over-expression on the rat mesangial cell fibrotic phenotype: effect of gender.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Jun 2012

Pawluczyk Izabella Z A, Harris Kevin P G

Abstract excerpt

BACKGROUND AND AIM: The protective role of angiotensin type 2 receptors (AT2-Rs) is still controversial. As AT2-Rs are minimally expressed in adult tissues the aim of the current study was to over-express AT2-Rs in rat mesangial cells in order to ascertain their potential role in modulating renal scarring. METHODS: Male and female mesangial cells were transiently transfected with AT2-R or control vector then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibronectins
Share to Fibrosis
Share to Kallikreins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Matrix Metalloproteinases

Share to Nitric Oxide Synthase

Share to Rats, Wistar

Share to Receptor, Angiotensin, Type 1

Share to Receptor, Angiotensin, Type 2

Source

Identifiers

PMID: 22287496
DOI: 10.1177/1470320311432185

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of angiotensin type 2 receptor over-expression on the rat mesangial cell fibrotic phenotype: effect of gender.PMID 22287496Read ↗

Rat mesangial cells exhibit sex-specific profibrotic and proinflammatory phenotypes.Semantic proximity Read ↗

Kallikrein gene 'knock-down' by small interfering RNA transfection induces a profibrotic phenotype in rat mesangial cells.Semantic proximity Read ↗

Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats.Semantic proximity Read ↗

Genetic deletion and overexpression of angiotensin II receptors.Semantic proximity Read ↗

Growth-dependent induction of angiotensin II type 2 receptor in rat mesangial cells.Semantic proximity Read ↗

Ets-1 Targeted by MicroRNA-221 Regulates Angiotensin II-Induced Renal Fibroblast Activation and FibrosisSemantic proximity Read ↗

Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosisSemantic proximity Read ↗

Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.Semantic proximity Read ↗

Down-regulation of cyclooxygenase-2 by the carboxyl tail of the angiotensin II type 1 receptor.Semantic proximity Read ↗

Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II-Induced Medial Hyperplasia in the Ascending Aorta.Semantic proximity Read ↗

Angiotensin II-induced modulation of rat mesangial cell phenotype.Semantic proximity Read ↗

Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.