Article
Effect of angiotensin type 2 receptor over-expression on the rat mesangial cell fibrotic phenotype: effect of gender.
Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Jun 2012
Pawluczyk Izabella Z A, Harris Kevin P G
Abstract excerpt
BACKGROUND AND AIM: The protective role of angiotensin type 2 receptors (AT2-Rs) is still controversial. As AT2-Rs are minimally expressed in adult tissues the aim of the current study was to over-express AT2-Rs in rat mesangial cells in order to ascertain their potential role in modulating renal scarring. METHODS: Male and female mesangial cells were transiently transfected with AT2-R or control vector then...
Topics
- Animals
- Cytokines
- Female
- Fibronectins
- Fibrosis
- Gene Expression Regulation
- Kallikreins
- Male
- Matrix Metalloproteinases
- Mesangial Cells
- Nitric Oxide Synthase
- Phenotype
- Rats
- Rats, Wistar
- Receptor, Angiotensin, Type 1
- Receptor, Angiotensin, Type 2
- Receptors, Bradykinin
- Sex Characteristics