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Article

Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice.

American journal of physiology. Renal physiology - 1 Oct 2020

Yamashita Noriyuki, Kusaba Tetsuro, Nakata Tomohiro, Tomita Aya, Ida Tomoharu, Watanabe-Uehara Noriko, Ikeda Kisho, Kitani Takashi, Uehara Masahiro, Kirita Yuhei, Matoba Satoaki, Humphreys Benjamin D, Tamagaki Keiichi

Abstract excerpt

Tubular atrophy is a common pathological feature of kidney fibrosis. Although fibroblasts play a predominant role in tissue fibrosis, the role of repairing tubular epithelia in tubular atrophy is unclear. We demonstrated the essential role of focal adhesion kinase (FAK)-mediated intratubular epithelial-mesenchymal transition (EMT) in the pathogenesis of tubular atrophy after severe ischemia-reperfusion injury...

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Identifiers

PMID: 32799673
DOI: 10.1152/ajprenal.00108.2020

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