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Article

Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.

Biochemical pharmacology - 1 Jan 2021

Guo Yangyang, Xiao Yanyi, Zhu Hengyue, Guo Hangcheng, Zhou Ying, Shentu Yangping, Zheng Chenfei, Chen Chaosheng, Bai Yongheng

Abstract excerpt

Renal fibrosis is a frequent axis contributing to the occurrence of end-stage nephropathy. Previously, it has been reported that atractylenolide Ⅰ (ATL-1), a natural compound extracted from Atractylodes macrocephala, has anti-cancer and antioxidant effects. However, the renal anti-fibrotic effects of action remain unclear. In this study, the anti-fibrotic effects of ATL-1 were examined in fibroblasts, tubular...

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Identifiers

PMID: 33221275
DOI: 10.1016/j.bcp.2020.114344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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