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HK-2 cell response to TGF-β highly depends on cell culture medium formulations

26 Sept 2023

Abstract excerpt

The immortalized human renal proximal tubular epithelial cell line HK-2 is most commonly used to study renal cell physiology and human kidney diseases with tubulointerstitial fibrosis such as diabetic nephropathy, obstructive uropathy or allograft fibrosis. Epithelial-to-mesenchymal transition (EMT) is the main pathological process of tubulointerstitial fibrosis in vitro. Transforming growth factor-beta (TGF-β)...

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PMID: 37752256
DOI: 10.1007/s00418-023-02237-x

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