Article
YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5.
Molecular biology of the cell - 1 Oct 2008
Sucharov Carmen C, Dockstader Karen, McKinsey Timothy A
Abstract excerpt
YY1 is a transcription factor that can repress or activate the transcription of a variety of genes. Here, we show that the function of YY1 as a repressor in cardiac myocytes is tightly dependent on its ability to interact with histone deacetylase 5 (HDAC5). YY1 interacts with HDAC5, and overexpression of YY1 prevents HDAC5 nuclear export in response to hypertrophic stimuli and the increase in cell size and...
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