Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yin Yang 1 Is Increased in Human Heart Failure and Represses the Activity of the Human α-Myosin Heavy Chain Promoter

1 Aug 2003

Abstract excerpt

Yin Yang 1 (YY1) is a transcription factor that can repress or activate transcription of the genes with which it interacts. In this report we show that YY1 is a negative regulator of the alpha-myosin heavy chain (alphaMyHC) gene, which, with betaMyHC are the molecular motors of the heart. AlphaMyHC mRNA and protein levels are down-regulated in hypertrophy and heart failure, and this is thought to be detrimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Healthcare and Venom Research
Share to Muscle Physiology and Disorders

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12754214
DOI: 10.1074/jbc.m301917200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yin Yang 1 Is Increased in Human Heart Failure and Represses the Activity of the Human α-Myosin Heavy Chain PromoterPMID 12754214Read ↗

The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene ExpressionSemantic proximity Read ↗

Endothelin-Stimulated Human B-Type Natriuretic Peptide Gene Expression Is Mediated by Yin Yang 1 in Association With Histone Deacetylase 2Semantic proximity Read ↗

YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5.Semantic proximity Read ↗

Regulation of Yin Yang 1 by Tyrosine Phosphorylation.Semantic proximity Read ↗

YY1 is a positive regulator of transcription of the Col1a1 gene.Semantic proximity Read ↗

Interleukin-1beta is a negative transcriptional regulator of alpha1-adrenergic induced gene expression in cultured cardiac myocytes.Semantic proximity Read ↗

Targeted Disruption of Mouse Yin Yang 1 Transcription Factor Results in Peri-Implantation LethalitySemantic proximity Read ↗

Yin-Yang 1 Activates Interleukin-4 Gene Expression in T CellsSemantic proximity Read ↗

Multifunctional transcription factor YY1: a therapeutic target in human cancer?Semantic proximity Read ↗

Role for a YY1-binding element in replication-dependent mouse histone gene expression.Semantic proximity Read ↗

Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4Semantic proximity Read ↗

Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.