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Article

The role of macrophage in the pathogenesis of chronic cyclosporine-induced nephropathy

13 Jul 2008

Abstract excerpt

BACKGROUND: Macrophages play diverse roles in tissue injury. We evaluated their role in cyclosporine (CsA)-induced renal injury by depletion with liposomal clodronate (CL). METHODS: Male Sprague Dawley rats were treated with CsA with or without CL treatment for 28 days. We assessed responses from the pathology and by measuring renal functions and levels of a proinflammatory cytokine (osteopontin), a profibrotic...

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PMID: 18622021
DOI: 10.1093/ndt/gfn388

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