Article
Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury.
Pediatric nephrology (Berlin, Germany) - 1 Jun 2015
Ikezumi Yohei, Suzuki Toshiaki, Yamada Takeshi, Hasegawa Hiroya, Kaneko Utako, Hara Masanori, Yanagihara Toshio, Nikolic-Paterson David J, Saitoh Akihiko
Abstract excerpt
BACKGROUND: Prevention of chronic kidney allograft injury (CAI) is a major goal in improving kidney allograft survival; however, the mechanisms of CAI are not clearly understood. The current study investigated whether alternatively activated M2-type macrophages are involved in the development of CAI. METHODS: A retrospective study examined kidney allograft protocol biopsies (at 1 h and at years 1, 5, and 10--a...
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