Macrophage phenotype and renal fibrosis in obstructive nephropathy.

Abstract excerpt

Macrophages have classically been recognized as key players that may promote renal fibrosis. However, several recent studies have suggested a beneficial anti-fibrotic role of infiltrating macrophages that acts to preserve renal architecture in the progressive renal scarring associated with obstructive nephropathy. Furthermore, recent investigations indicate a role for macrophages in both inflammation and repair...

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