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Article

Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching.

American journal of physiology. Renal physiology - 1 Mar 2021

Zhao Yu, Zhu Xiang-Yang, Song Turun, Zhang Lei, Eirin Alfonso, Conley Sabena, Tang Hui, Saadiq Ishran, Jordan Kyra, Lerman Amir, Lerman Lilach O

Abstract excerpt

Tumor necrosis factor (TNF)-α-induced gene/protein (TSG)-6 regulates the immunomodulatory properties of mesenchymal stem cells (MSCs), but its ability to protect the ischemic kidney is unknown. In a swine model of renal artery stenosis (RAS) and metabolic syndrome (MetS), we assessed the contribution of TSG-6 produced by MSCs to their immunomodulatory properties. Pigs were studied after 16 wk of diet-induced MetS...

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Identifiers

PMID: 33554782
DOI: 10.1152/ajprenal.00426.2020
PMCID: PMC7988807

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TNF
MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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