Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms.

doi:10.1080/10985549.2025.2529837

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Article

Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms.

Molecular and cellular biology - 1 Jan 2025

Saleiro Diana, Wen Jeremy Q, Zannikou Markella, Lee Brian, Kosciuczuk Ewa M, Nehlsen Sarah D, Munshi Adam, Chen Xintong, Oku Chidera V, Hryhorysak Briana, Guillen Magaña Jamie N, Heneche Jorge, Fischietti Mariafausta, Ilut Liliana, Small Sara H, Cotton Anitria, Hall Trent, Payton Monique A, Beauchamp Elspeth M, Yue Feng, Kocherginsky Masha, Bartom Elizabeth T, Hoffman Ronald, Crispino John D, Platanias Leonidas C

Abstract excerpt

Defining the mechanisms that promote development and progression of myeloproliferative neoplasms (MPNs) is important for understanding the mechanisms of malignant hematopoiesis and critical development of new treatment approaches. We provide evidence for a key and essential role of the kinase ULK1 in MPN pathophysiology. Our studies demonstrate that genetic or pharmacological targeting of ULK1 delays...

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Identifiers

PMID: 40697155
DOI: 10.1080/10985549.2025.2529837
PMCID: PMC12645588

Genes

ULK1
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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