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Article

Critical Role of Jak2 in the Maintenance and Function of Adult Hematopoietic Stem Cells

26 Mar 2014

Abstract excerpt

Jak2, a member of the Janus kinase family of nonreceptor protein tyrosine kinases, is activated in response to a variety of cytokines, and functions in survival and proliferation of cells. An activating JAK2V617F mutation has been found in most patients with myeloproliferative neoplasms, and patients treated with Jak2 inhibitors show significant hematopoietic toxicities. However, the role of Jak2 in adult...

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PMID: 24677703
DOI: 10.1002/stem.1711

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