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Article

The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.

Biological psychiatry - 1 Jun 2008

Schlaepfer Isabel R, Hoft Nicole R, Collins Allan C, Corley Robin P, Hewitt John K, Hopfer Christian J, Lessem Jeffrey M, McQueen Matthew B, Rhee Soo Hyun, Ehringer Marissa A

Abstract excerpt

BACKGROUND: One potential site of convergence of the nicotine and alcohol actions is the family of the neuronal nicotinic acetylcholine receptors. Our study examines the genetic association between variations in the genomic region containing the CHRNA5, A3, and B4 gene cluster (A5A3B4) and several phenotypes of alcohol and tobacco use in an ethnically diverse young adult sample. Significant results were then...

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Source

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Identifiers

PMID: 18163978
DOI: 10.1016/j.biopsych.2007.10.024
PMCID: PMC2526976

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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