Article
The association between APOE genotype and memory dysfunction in subjects with mild cognitive impairment is related to age and Alzheimer pathology.
Dementia and geriatric cognitive disorders - 1 Jan 2008
Ramakers I H G B, Visser P J, Aalten P, Bekers O, Sleegers K, van Broeckhoven C L, Jolles J, Verhey F R J
Abstract excerpt
BACKGROUND: Memory problems are a main feature of mild cognitive impairment (MCI) and may be related to the apolipoprotein E (APOE) epsilon4 allele. We investigated whether the effect of the APOE genotype on memory in subjects with MCI was dependent on age and underlying Alzheimer disease (AD) pathology. METHODS: Subjects with MCI (n = 180) were selected from a memory clinic setting. Subjects with at least one...
Topics
- Aged
- Alzheimer Disease
- Apolipoprotein E4
- Cognition Disorders
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- Logistic Models