Article
The effect of APOE genotype on clinical phenotype in Alzheimer disease.
Neurology - 8 Aug 2006
van der Flier W M, Schoonenboom S N M, Pijnenburg Y A L, Fox N C, Scheltens P
Abstract excerpt
The authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-epsilon4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-epsilon4 allele, whereas the atypical...
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