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Human Papillomavirus E7 Induces Rereplication in Response to DNA Damage

15 Nov 2012

Abstract excerpt

Human papillomavirus (HPV) infection is necessary but not sufficient for cervical carcinogenesis. Genomic instability caused by HPV allows cells to acquire additional mutations required for malignant transformation. Genomic instability in the form of polyploidy has been demonstrated to play an important role in cervical carcinogenesis. We have recently found that HPV-16 E7 oncogene induces polyploidy in response...

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PMID: 23152514
DOI: 10.1128/jvi.02038-12

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Human Papillomavirus E7 Induces Rereplication in Response to DNA DamagePMID 23152514Read ↗

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