Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor.

doi:10.1083/jcb.117.3.493

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Article

Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor.

The Journal of cell biology - 1 May 1992

Rapiejko P J, Gilmore R

Abstract excerpt

The signal recognition particle (SRP)-mediated translocation of proteins across the RER is a GTP dependent process. Analysis of the primary amino acid sequence of one protein subunit of SRP (SRP54), as well as the alpha subunit of the SRP receptor (SR alpha), has indicated that these proteins con...

Topics

Animals
Base Sequence
Binding Sites
Biological Transport, Active
Consensus Sequence
Dogs
Endoplasmic Reticulum
Eye Proteins
Guanosine Triphosphate
Guanylyl Imidodiphosphate
Macromolecular Substances
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Mutation

Pancreas

Protein Biosynthesis

Receptors, Cell Surface

Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 1315314
DOI: 10.1083/jcb.117.3.493
PMCID: PMC2289435

Genes

SRP54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1315314-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor.PMID 1315314Read ↗

Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP.Semantic proximity Read ↗

Demonstration of a multistep mechanism for assembly of the SRP x SRP receptor complex: implications for the catalytic role of SRP RNA.Semantic proximity Read ↗

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.Semantic proximity Read ↗

A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins.Semantic proximity Read ↗

The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.Semantic proximity Read ↗

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