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Article

Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor.

The Journal of cell biology - 1 May 1992

Rapiejko P J, Gilmore R

Abstract excerpt

The signal recognition particle (SRP)-mediated translocation of proteins across the RER is a GTP dependent process. Analysis of the primary amino acid sequence of one protein subunit of SRP (SRP54), as well as the alpha subunit of the SRP receptor (SR alpha), has indicated that these proteins contain predicted GTP binding sites. Several point mutations confined to the GTP binding consensus elements of SR alpha...

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Identifiers

PMID: 1315314
DOI: 10.1083/jcb.117.3.493
PMCID: PMC2289435

Genes

SRP54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor.PMID 1315314Read ↗

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