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Article

Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle.

RNA biology - 1 Jan 2000

van Nues Rob W, Leung Eileen, McDonald James C, Dantuluru Iswarya, Brown Jeremy D

Abstract excerpt

Co-translational protein targeting to the endoplasmic reticulum is catalysed by the signal recognition particle, a conserved ribonucleoprotein. Key activities of SRP--signal sequence binding, and inhibition of ribosomal translation elongation--require interactions of SRP with distant locations on the ribosome. A heterodimer of Srp72p and Srp68p localise to the central portion of the SRP complex, and may...

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Identifiers

PMID: 18418087
DOI: 10.4161/rna.5.2.6042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle.PMID 18418087Read ↗

Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.Semantic proximity Read ↗

Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis.Semantic proximity Read ↗

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Distant segments of Saccharomyces cerevisiae scR1 RNA promote assembly and function of the signal recognition particle.Semantic proximity Read ↗

Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia.Semantic proximity Read ↗

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.Semantic proximity Read ↗

Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.Semantic proximity Read ↗

A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins.Semantic proximity Read ↗

Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p.Semantic proximity Read ↗

The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.Semantic proximity Read ↗

A previously uncharacterized role for small protein B (SmpB) in transfer messenger RNA-mediated trans-translation.Semantic proximity Read ↗

Access to ribosomal protein Rpl25p by the signal recognition particle is required for efficient cotranslational translocation.Semantic proximity Read ↗

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