Article

GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis

2021-01-19

Abstract excerpt

<title>Abstract</title> <p>Growth differentiation factor 11 (GDF11) is a transforming factor-β superfamily member that functions as a negative regulator of neurogenesis during embryonic development. However, when recombinant GDF11 (rGDF11) is administered systemically in aged mice, it promotes neurogenesis, the opposite of its role during development. The goal of the present study was to reconcile this apparent d...

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Literature Corpus work: 92948d93-9669-5941-b0b4-985ae6f1fbc9
DOI: 10.21203/rs.3.rs-148652/v1

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