Article
Generation of a conditional allele of the B-myb gene.
Genesis (New York, N.Y. : 2000) - 1 Dec 2005
García Paloma, Berlanga Oscar, Watson Roger, Frampton Jon
Abstract excerpt
B-Myb is an essential transcription factor involved in control of the cell cycle and the regulation of tissue-specific gene expression in a wide range of cell types. Loss of both alleles results in early embryonic lethality at E4.5-6.5. To address the function of B-Myb in later stages of embryogenesis and in specific adult tissues, a floxed B-myb allele (B-mybF) was generated. Cre-mediated deletion in vivo was...
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