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Article

Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.

The EMBO journal - 2 May 2007

Rougemaille Mathieu, Gudipati Rajani Kanth, Olesen Jens Raabjerg, Thomsen Rune, Seraphin Bertrand, Libri Domenico, Jensen Torben Heick

Abstract excerpt

The nuclear exosome is involved in numerous RNA metabolic processes. Exosome degradation of rRNA, snoRNA, snRNA and tRNA in Saccharomyces cerevisiae is activated by TRAMP complexes, containing either the Trf4p or Trf5p poly(A) polymerase. These enzymes are presumed to facilitate exosome access by appending oligo(A)-tails onto structured substrates. Another role of the nuclear exosome is that of mRNA surveillance....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17410208
DOI: 10.1038/sj.emboj.7601669
PMCID: PMC1864968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.PMID 17410208Read ↗

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