Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.

Cell - 17 Oct 2008

Rougemaille Mathieu, Dieppois Guennaelle, Kisseleva-Romanova Elena, Gudipati Rajani Kanth, Lemoine Sophie, Blugeon Corinne, Boulay Jocelyne, Jensen Torben Heick, Stutz Françoise, Devaux Frédéric, Libri Domenico

Abstract excerpt

During transcription, proteins assemble sequentially with nascent RNA to generate a messenger ribonucleoprotein particle (mRNP). The THO complex and its associated Sub2p helicase are functionally implicated in both transcription and mRNP biogenesis but their precise function remains elusive. We s...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Nuclear Pore

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleocytoplasmic Transport Proteins

Share to Nucleosomes

Share to Ribonucleoproteins

Share to RNA, Fungal

Share to RNA Polymerase II

Share to RNA Transport

Source

Identifiers

PMID: 18957205
DOI: 10.1016/j.cell.2008.08.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18957205-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.PMID 18957205Read ↗

Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation.Semantic proximity Read ↗

Mutational analysis of the yeast RNA helicase Sub2p reveals conserved domains required for growth, mRNA export, and genomic stability.Semantic proximity Read ↗

The THO complex in Schizosaccharomyces pombe-dissecting the composition and functional hierarchy.Semantic proximity Read ↗

Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.Semantic proximity Read ↗

Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Semantic proximity Read ↗

Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment.Semantic proximity Read ↗

New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.Semantic proximity Read ↗

The DECD box putative ATPase Sub2p is an early mRNA export factor.Semantic proximity Read ↗

Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.Semantic proximity Read ↗

The THO complex as a key mRNP biogenesis factor in development and cell differentiation.Semantic proximity Read ↗

RNA binding is essential for NONO condensates to modulate pre-mRNA processing of super enhancer-associated genes in neuroblastomaSemantic proximity Read ↗

Multiple Quality Control Checkpoints Safeguard Small Nuclear RNA Biogenesis and Prevent Assembly of Aberrant SpliceosomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.