Article

Constitutive, mosaic expression of TIE2 p.L914F during mouse development causes formation of venous malformation

2026-01-28

Abstract excerpt

<h4>Background</h4> The hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase that is essential for vascular development and function, has been found to drive sporadic venous malformation (VM). While germline or early developmental expression of the mutation is thought to be lethal, mosaic or somatic expression is expected to result in VM disease. However, this has never been shown experimentally....

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Literature Corpus work: 7186824b-b8f4-585f-aca8-9026e0b67dcb
DOI: 10.64898/2026.01.27.702061

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