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Article

Dysregulation of purine nucleotide biosynthesis pathways modulates cisplatin cytotoxicity in Saccharomyces cerevisiae.

Molecular pharmacology - 1 Oct 2008

Kowalski David, Pendyala Lakshmi, Daignan-Fornier Bertrand, Howell Stephen B, Huang Ruea-Yea

Abstract excerpt

We found previously that inactivation of the FCY2 gene, encoding a purine-cytosine permease, or the HPT1 gene, encoding the hypoxanthine guanine phosphoribosyl transferase, enhances cisplatin resistance in yeast cells. Here, we report that in addition to fcy2Delta and hpt1Delta mutants in the salvage pathway of purine nucleotide biosynthesis, mutants in the de novo pathway that disable the feedback inhibition of...

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Identifiers

PMID: 18612078
DOI: 10.1124/mol.108.048256
PMCID: PMC2574737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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