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Article

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Mismatch Repair Mutants.

G3 (Bethesda, Md.) - 21 Jul 2015

Ojini Irene, Gammie Alison

Abstract excerpt

Resistance to cancer therapy is a major obstacle in the long-term treatment of cancer. A greater understanding of drug resistance mechanisms will ultimately lead to the development of effective therapeutic strategies to prevent resistance from occurring. Here, we exploit the mutator phenotype of mismatch repair defective yeast cells combined with whole genome sequencing to identify drug resistance mutations in...

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PMID: 26199284
DOI: 10.1534/g3.115.020560
PMCID: PMC4555229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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