Drug resistance in diploid yeast is acquired through dominant alleles, haploinsufficiency, gene duplication and aneuploidy.

doi:10.1371/journal.pgen.1009800

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Article

Drug resistance in diploid yeast is acquired through dominant alleles, haploinsufficiency, gene duplication and aneuploidy.

PLoS genetics - 1 Sept 2021

Barney Jordan B, Chandrashekarappa Dakshayini G, Soncini Samantha R, Schmidt Martin C

Abstract excerpt

Previous studies of adaptation to the glucose analog, 2-deoxyglucose, by Saccharomyces cerevisiae have utilized haploid cells. In this study, diploid cells were used in the hope of identifying the distinct genetic mechanisms used by diploid cells to acquire drug resistance. While haploid cells acquire resistance to 2-deoxyglucose primarily through recessive alleles in specific genes, diploid cells acquire...

Topics

Alleles
Aneuploidy
Chromosomes, Fungal
Deoxyglucose
Diploidy
Drug Resistance, Fungal
Gene Duplication
Genes, Dominant
Haploinsufficiency
Mutation
Saccharomyces cerevisiae
Whole Genome Sequencing

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Identifiers

PMID: 34555030
DOI: 10.1371/journal.pgen.1009800
PMCID: PMC8460028

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