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Article

Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin- and doxorubicin-provoked cell kill.

Molecular pharmacology - 1 Aug 2003

Schenk Paul W, Brok Mariel, Boersma Antonius W M, Brandsma Jourica A, Den Dulk Hans, Burger Herman, Stoter Gerrit, Brouwer Jaap, Nooter Kees

Abstract excerpt

The therapeutic potential of antitumor drugs is seriously limited by the manifestation of cellular drug resistance. We used the budding yeast Saccharomyces cerevisiae as a model system to identify novel mechanisms of resistance to one of the most active anticancer agents, cisplatin. We pinpointed NPR2 (nitrogen permease regulator 2) as a gene whose disruption conferred resistance to cisplatin. In addition, we...

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Source

Identifiers

PMID: 12869630
DOI: 10.1124/mol.64.2.259

Genes

NPR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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