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Article

The isolation and characterization of Saccharomyces cerevisiae mutants that constitutively express purine biosynthetic genes.

Genetics - 1 Oct 1997

Guetsova M L, Lecoq K, Daignan-Fornier B

Abstract excerpt

In response to an external source of adenine, yeast cells repress the expression of purine biosynthesis pathway genes. To identify necessary components of this signalling mechanism, we have isolated mutants that are constitutively active for expression. These mutants were named bra (for bypass of repression by adenine). BRA7 is allelic to FCY2, the gene encoding the purine cytosine permease and BRA9 is ADE12, the...

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Identifiers

PMID: 9335580
DOI: 10.1093/genetics/147.2.383
PMCID: PMC1208165

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