Article
The isolation and characterization of Saccharomyces cerevisiae mutants that constitutively express purine biosynthetic genes.
Genetics - 1 Oct 1997
Guetsova M L, Lecoq K, Daignan-Fornier B
Abstract excerpt
In response to an external source of adenine, yeast cells repress the expression of purine biosynthesis pathway genes. To identify necessary components of this signalling mechanism, we have isolated mutants that are constitutively active for expression. These mutants were named bra (for bypass of...
Topics
- Adenine
- Adenosine Diphosphate
- Adenylosuccinate Lyase
- Amino Acid Sequence
- Genes, Fungal
- Genetic Complementation Test
- Hypoxanthine Phosphoribosyltransferase
- Molecular Sequence Data
- Mutation
- Phenotype
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid
- Signal Transduction