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Article

Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.

The Journal of biological chemistry - 5 Sept 2008

Okumura Fumihiko, Lenschow Deborah J, Zhang Dong-Er

Abstract excerpt

The expression of the ubiquitin-like molecule ISG15 (UCRP) and protein modification by ISG15 (ISGylation) are strongly activated by interferon, genotoxic stress, and pathogen infection, suggesting that ISG15 plays an important role in innate immune responses. Inducible nitric-oxide synthase (iNOS...

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Source

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Identifiers

PMID: 18606809
DOI: 10.1074/jbc.M803795200
PMCID: PMC2528991

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18606809-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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