Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wnt signaling genes of murine chromosome 15 are involved in sex-affected pathways of inflammatory arthritis.

Arthritis and rheumatism - 1 Apr 2012

Kudryavtseva Elena, Forde Toni S, Pucker Andrew D, Adarichev Vyacheslav A

Abstract excerpt

OBJECTIVE: Sex disparities in rheumatoid arthritis (RA) are well documented despite the lack of any known major RA susceptibility genes mapped to sex chromosomes. Murine chromosome 15 carries the sex-affected Pgia8 locus that mediates proteoglycan-induced arthritis, and homologous human loci are associated with RA. This study was undertaken to identify genes/mechanisms implicated in sex disparities in arthritis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Experimental
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 15

Share to Disease Models, Animal

Share to Gene Expression

Share to Severity of Illness Index

Share to Sex Factors

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 22005949
DOI: 10.1002/art.33414
PMCID: PMC3288823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wnt signaling genes of murine chromosome 15 are involved in sex-affected pathways of inflammatory arthritis.PMID 22005949Read ↗

Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation.Semantic proximity Read ↗

Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clustersSemantic proximity Read ↗

<i>ARL15</i> promotes inflammatory fibroblast activation and disease severity in rheumatoid arthritis: integrated transcriptomic and collagen-induced arthritis model analysesSemantic proximity Read ↗

Bioinformatics Analysis to Identify Key Genes and Pathways Associated with Sex Differences in Rheumatoid ArthritisSemantic proximity Read ↗

Genetics, Epigenetics, and Gender Impact in Axial-Spondyloarthritis Susceptibility: An Update on Genetic Polymorphisms and Their Sex Related AssociationsSemantic proximity Read ↗

Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis.Semantic proximity Read ↗

Synovial expression of Th17-related and cancer-associated genes is regulated by the arthritis severity locus Cia10.Semantic proximity Read ↗

Polymorphonuclear Myeloid-Derived Suppressor Cells Promote Inflammation Progression of Rheumatoid Arthritis by Inducing Age-Associated B Cell Proliferation and Differentiation via the BAFF-Mediated SYK-ERK1/2 PathwaySemantic proximity Read ↗

Rheumatoid arthritis is a heterogeneous disease: Evidence for differences in the activation of the STAT‐1 pathway between rheumatoid tissuesSemantic proximity Read ↗

Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis.Semantic proximity Read ↗

Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy.Semantic proximity Read ↗

Mechanisms of Sex Differences in Ankylosing Spondylitis: Interleukin 2 Receptor Subunit Beta and CD3d Molecule Play an Important RoleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.