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Article

Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura.

Gene - 1 Jan 2013

Gonçalves Flavia M, Martins-Oliveira Alisson, Lacchini Riccardo, Belo Vanessa A, Speciali Jose G, Dach Fabíola, Tanus-Santos Jose E

Abstract excerpt

Matrix metalloproteinases (MMP) are involved in the disruption of blood-brain barrier (BBB) during migraine attacks. In the present study, we hypothesized that two functional polymorphisms (C(-1306)T and C(-735)T) in MMP-2 gene and MMP-2 haplotypes are associated with migraine and modify MMP-2 and tissue inhibitor of MMP (TIMP)-2 levels in migraine. Genotypes for MMP-2 polymorphisms were determined by real...

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Identifiers

PMID: 23043936
DOI: 10.1016/j.gene.2012.09.109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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