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Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in <i>Caenorhabditis elegans</i>

2023-12-13

Abstract excerpt

The UFD-1 (ubiquitin fusion degradation 1)-NPL-4 (nuclear protein localization homolog 4) heterodimer is involved in extracting ubiquitinated proteins from several plasma membrane locations, including the endoplasmic reticulum. This heterodimer complex helps in the degradation of ubiquitinated proteins via the proteasome with the help of the AAA+ ATPase CDC-48. While the ubiquitin-proteasome system is known to hav...

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Literature Corpus work
e3440aa3-89d8-59b3-ad15-b78d3c03b6d2
DOI
10.1101/2023.12.12.571255
Open publication

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Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in <i>Caenorhabditis elegans</i>DOI 10.1101/2023.12.12.571255
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