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Article

Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes.

Science (New York, N.Y.) - 6 May 2011

Sun Jingru, Singh Varsha, Kajino-Sakamoto Rie, Aballay Alejandro

Abstract excerpt

The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway...

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Identifiers

PMID: 21474712
DOI: 10.1126/science.1203411
PMCID: PMC3125668

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