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Article

High-producing MBL2 genotypes increase the risk of acute and chronic carditis in patients with history of rheumatic fever.

Molecular immunology - 1 Aug 2008

Schafranski Marcelo Derbli, Pereira Ferrari Lílian, Scherner Daniela, Torres Renato, Jensenius Jens Christian, de Messias-Reason Iara José

Abstract excerpt

Rheumatic fever (RF) and its most severe sequela, chronic rheumatic heart disease (CRHD), are mediated by an abnormal immunological host response following a Streptococcus pyogenes oropharyngeal infection. Mannan-binding lectin (MBL), a collectin that activates complement, binds to N-acetylglucosamine, a molecule present on the streptococcus cell wall and on human heart valves. As high levels of MBL and MBL2...

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Source

Identifiers

PMID: 18602696
DOI: 10.1016/j.molimm.2008.05.013

Genes

MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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