Article
Association of MASP2 polymorphisms and protein levels with rheumatic fever and rheumatic heart disease.
Human immunology - 1 Dec 2014
Catarino Sandra Jeremias dos Santos, Boldt Angelica Beate Winter, Beltrame Marcia Holsbach, Nisihara Renato Mitsunori, Schafranski Marcelo Derbli, de Messias-Reason Iara Jose
Abstract excerpt
MASP-2 is a key protein of the lectin pathway of complement system. Several MASP2 polymorphisms were associated with MASP-2 serum levels or functional activity. Here we investigated a possible association between MASP2 polymorphisms and MASP-2 serum levels with the susceptibility to rheumatic fever (RF) and rheumatic heart disease (RHD). We haplotyped 11 MASP2 polymorphisms with multiplex sequence-specific PCR in...
Topics
- Adolescent
- Adult
- Base Sequence
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Male
- Mannose-Binding Protein-Associated Serine Proteases
- Middle Aged
- Polymorphism, Single Nucleotide
- Rheumatic Fever