Article
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008
Barbosa Ana C, Kim Mi-Sung, Ertunc Mert, Adachi Megumi, Nelson Erika D, McAnally John, Richardson James A, Kavalali Ege T, Monteggia Lisa M, Bassel-Duby Rhonda, Olson Eric N
Abstract excerpt
Learning and memory depend on the activity-dependent structural plasticity of synapses and changes in neuronal gene expression. We show that deletion of the MEF2C transcription factor in the CNS of mice impairs hippocampal-dependent learning and memory. Unexpectedly, these behavioral changes were accompanied by a marked increase in the number of excitatory synapses and potentiation of basal and evoked synaptic...
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