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Article

MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Aug 2013

Elmer Bradford M, Estes Myka L, Barrow Stephanie L, McAllister A Kimberley

Abstract excerpt

Major histocompatibility complex class I (MHCI) molecules negatively regulate cortical connections and are implicated in neurodevelopmental disorders, including autism spectrum disorders and schizophrenia. However, the mechanisms that mediate these effects are unknown. Here, we report a novel MHCI signaling pathway that requires the myocyte enhancer factor 2 (MEF2) transcription factors. In young rat cortical...

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Identifiers

PMID: 23966700
DOI: 10.1523/JNEUROSCI.2366-13.2013
PMCID: PMC3755720

Genes

MIA

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