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Article

Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number.

Science (New York, N.Y.) - 17 Feb 2006

Flavell Steven W, Cowan Christopher W, Kim Tae-Kyung, Greer Paul L, Lin Yingxi, Paradis Suzanne, Griffith Eric C, Hu Linda S, Chen Chinfei, Greenberg Michael E

Abstract excerpt

In the mammalian nervous system, neuronal activity regulates the strength and number of synapses formed. The genetic program that coordinates this process is poorly understood. We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocampal neurons formed synapses. In response to increased neuronal...

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PMID: 16484497
DOI: 10.1126/science.1122511

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