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Article

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008

Li Hao, Radford Jonathan C, Ragusa Michael J, Shea Katherine L, McKercher Scott R, Zaremba Jeffrey D, Soussou Walid, Nie Zhiguo, Kang Yeon-Joo, Nakanishi Nobuki, Okamoto Shu-ichi, Roberts Amanda J, Schwarz John J, Lipton Stuart A

Abstract excerpt

Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex. Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal differentiation in vivo, resulting in aberrant compaction and smaller somal size. NSC...

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Identifiers

PMID: 18599437
DOI: 10.1073/pnas.0802876105
PMCID: PMC2453715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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