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Article

Targeting gastrin releasing peptide receptors: New options for the therapy and diagnosis of cancer

1 May 2010

Abstract excerpt

Gastrin-releasing peptide (GRP), the mammalian bombesin (BN), appears to be involved in the growth of several neoplasms. BN/GRP receptors (BN/GRP-Rs) are expressed in a variety of cancer cells and have limited distribution in normal human tissue. Thus inhibition of BN/GRP-Rs represents an attractive target for pharmacological treatment of some human malignancies. This review will focus on intracellular signaling...

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PMID: 20473035
DOI: 10.4161/cc.9.9.11347

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