Article

Ligand-specific regulation and signalling by the neuromedin U 2 receptor

2019-01-01

Abstract excerpt

Neuromedin U receptor 2 (NMU2) is a Family A, G protein-coupled receptor (GPCR) for both neuromedin U (NmU) and neuromedin S (NmS), particularly within the CNS where effects include the suppression of feeding behaviour and increased energy expenditure suggesting an anti-obesity target. Although NMU2 preferentially activates Gαq/11, it is unclear which signalling underlies physiological outcomes or if the ligands g...

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Literature Corpus work: 34b37170-2c07-5bd9-940a-508e1b5739ee
DOI: 10.25392/leicester.data.10303826.v1

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