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Article

Genetic variants in FKBP5 affecting response to antidepressant drug treatment.

Pharmacogenomics - 1 Jul 2008

Kirchheiner Julia, Lorch Rainer, Lebedeva Elena, Seeringer Angela, Roots Ivar, Sasse Johanna, Brockmöller Jürgen

Abstract excerpt

INTRODUCTION: Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is a pathogenic mechanism of depression, and genetic polymorphisms in HPA axis genes have been described to influence response to antidepressant drugs. In particular, two polymorphisms in FKBP5, a co-chaperone of the glucocorticoid receptor, were strongly associated with response to therapy. We aimed to analyze whether these findings...

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Source

Identifiers

PMID: 18597649
DOI: 10.2217/14622416.9.7.841

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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