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Article

Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits.

BMC psychiatry - 2 Nov 2006

Gawlik Micha, Moller-Ehrlich Kerstin, Mende Meinhard, Jovnerovski Michael, Jung Sven, Jabs Burkhard, Knapp Michael, Stoeber Gerald

Abstract excerpt

BACKGROUND: A dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an important pathogenic factor in depression. Genetic variants of FKBP5, a protein of the HPA system modulating the glucocorticoid receptor, have been reported to be genetically associated with improved response to medical treatment and an increase of depressive episodes. METHODS: We examined three single nucleotide...

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Source

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Identifiers

PMID: 17081296
DOI: 10.1186/1471-244X-6-52
PMCID: PMC1635032

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits.PMID 17081296Read ↗

FKBP5 polymorphism is associated with major depression but not with bipolar disorder.Semantic proximity Read ↗

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DNA sequence variants of the FKBP5 gene are associated with unipolar depression.Semantic proximity Read ↗

Family-based association of FKBP5 in bipolar disorder.Semantic proximity Read ↗

The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral PhenotypesSemantic proximity Read ↗

Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis.Semantic proximity Read ↗

Lack of association of FKBP5 SNPs and haplotypes with susceptibility and treatment response phenotypes in Han Chinese with major depressive disorder: A pilot case-control study (STROBE).Semantic proximity Read ↗

Genetic variants in FKBP5 affecting response to antidepressant drug treatment.Semantic proximity Read ↗

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Evidence Mounting for Gene-by-Environment Interactions at the FKBP5 Locus Predicting Psychiatric Symptoms.Semantic proximity Read ↗

Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model.Semantic proximity Read ↗

FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.Semantic proximity Read ↗

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