Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment.

doi:10.1038/ng1479

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Article

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment.

Nature genetics - 1 Dec 2004

Binder Elisabeth B, Salyakina Daria, Lichtner Peter, Wochnik Gabriele M, Ising Marcus, Pütz Benno, Papiol Sergi, Seaman Shaun, Lucae Susanne, Kohli Martin A, Nickel Thomas, Künzel Heike E, Fuchs Brigitte, Majer Matthias, Pfennig Andrea, Kern Nikola, Brunner Jürgen, Modell Sieglinde, Baghai Thomas, Deiml Tobias, Zill Peter, Bondy Brigitta, Rupprecht Rainer, Messer Thomas, Köhnlein Oliver, Dabitz Heike, Brückl Tanja, Müller Nina, Pfister Hildegard, Lieb Roselind, Mueller Jakob C, Lõhmussaar Elin, Strom Tim M, Bettecken Thomas, Meitinger Thomas, Uhr Manfred, Rein Theo, Holsboer Florian, Muller-Myhsok Bertram

Abstract excerpt

The stress hormone-regulating hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality as well as the treatment of depression. To investigate a possible association between genes regulating the HPA axis and response to antidepressants and susceptibility for depression, we ge...

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Identifiers

PMID: 15565110
DOI: 10.1038/ng1479

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15565110-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment.PMID 15565110Read ↗

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