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Article

FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.

Pharmacogenetics and genomics - 1 Mar 2013

Ellsworth Katarzyna A, Moon Irene, Eckloff Bruce W, Fridley Brooke L, Jenkins Gregory D, Batzler Anthony, Biernacka Joanna M, Abo Ryan, Brisbin Abra, Ji Yuan, Hebbring Scott, Wieben Eric D, Mrazek David A, Weinshilboum Richard M, Wang Liewei

Abstract excerpt

OBJECTIVES: FKBP51 (51 kDa immunophilin) acts as a modulator of the glucocorticoid receptor and a negative regulator of the Akt pathway. Genetic variation in FKBP5 plays a role in antidepressant response. The aim of this study was to comprehensively assess the role of genetic variation in FKBP5, identified by both Sanger and Next Generation DNA resequencing, as well as genome-wide single nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23324805
DOI: 10.1097/FPC.0b013e32835dc133
PMCID: PMC3784025

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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