The FKBP5 polymorphism rs1360780 influences the effect of an algorithm-based antidepressant treatment and is associated with remission in patients with major depression.

doi:10.1177/0269881115620459

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The FKBP5 polymorphism rs1360780 influences the effect of an algorithm-based antidepressant treatment and is associated with remission in patients with major depression.

Journal of psychopharmacology (Oxford, England) - 1 Jan 2016

Stamm Thomas J, Rampp Carina, Wiethoff Katja, Stingl Julia, Mössner Rainald, O Malley Grace, Ricken Roland, Seemüller Florian, Keck Martin, Fisher Robert, Gaebel Wolfgang, Maier Wolfgang, Möller Hans-Jürgen, Bauer Michael, Adli Mazda

Abstract excerpt

OBJECTIVE: The FKBP5-gene influences the HPA-system by modulating the sensitivity of the glucocorticoid receptor (GR). The polymorphism rs1360780 has been associated with response in studies with heterogeneous antidepressant treatment. In contrast, several antidepressant studies with standardized antidepressant treatment could not detect this effect. We therefore compared patients with standardized vs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antidepressive Agents

Share to Depressive Disorder, Major

Share to Germany

Share to Psychiatric Status Rating Scales

Share to Remission Induction

Share to Tacrolimus Binding Proteins

Share to Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 26645208
DOI: 10.1177/0269881115620459

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The FKBP5 polymorphism rs1360780 influences the effect of an algorithm-based antidepressant treatment and is associated with remission in patients with major depression.PMID 26645208Read ↗

Genetic variants in FKBP5 affecting response to antidepressant drug treatment.Semantic proximity Read ↗

The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort.Semantic proximity Read ↗

The association of FKBP5 gene polymorphism with genetic susceptibility to depression and response to antidepressant treatment- a systematic review.Semantic proximity Read ↗

Consensus paper of the WFSBP Task Force on Genetics: Genetics, epigenetics and gene expression markers of major depressive disorder and antidepressant responseSemantic proximity Read ↗

Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.Semantic proximity Read ↗

Lack of association of FKBP5 SNPs and haplotypes with susceptibility and treatment response phenotypes in Han Chinese with major depressive disorder: A pilot case-control study (STROBE).Semantic proximity Read ↗

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.Semantic proximity Read ↗

DNA sequence variants of the FKBP5 gene are associated with unipolar depression.Semantic proximity Read ↗

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment.Semantic proximity Read ↗

Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression.Semantic proximity Read ↗

FKBP5 polymorphism is associated with major depression but not with bipolar disorder.Semantic proximity Read ↗

Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.