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Article

Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2008

Plotkin Lilian I, Lezcano Virginia, Thostenson Jeff, Weinstein Robert S, Manolagas Stavros C, Bellido Teresita

Abstract excerpt

Connexin (Cx)43 is required for inhibition of osteocyte and osteoblast apoptosis by bisphosphonates in vitro. Herein, we evaluated its requirement for the in vivo actions of bisphosphonates using mice in which Cx43 was deleted specifically from osteocytes and osteoblasts (Cx43(DeltaOb-Ot/-) mice). Effective removal of Cx43 was confirmed by the presence of the deleted form of the gene and by reduced mRNA and...

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Identifiers

PMID: 18597631
DOI: 10.1359/jbmr.080617
PMCID: PMC2648607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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