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Article

Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling.

Molecular biology of the cell - 15 Apr 2011

Watkins Marcus, Grimston Susan K, Norris Jin Yi, Guillotin Bertrand, Shaw Angela, Beniash Elia, Civitelli Roberto

Abstract excerpt

Connexin43 (Cx43) has an important role in skeletal homeostasis, and Cx43 gene (Gja1) mutations have been linked to oculodentodigital dysplasia (ODDD), a human disorder characterized by prominent skeletal abnormalities. To determine the function of Cx43 at early steps of osteogenesis and its role in the ODDD skeletal phenotype, we have used the Dermo1 promoter to drive Gja1 ablation or induce an ODDD mutation in...

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Identifiers

PMID: 21346198
DOI: 10.1091/mbc.E10-07-0571
PMCID: PMC3078079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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